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Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model
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Titel: | Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model/ David Reher, Barbara Klink, Andreas Deutsch and Anja Voss-Böhme |
veröffentlicht: |
11 August 2017
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Enthalten in: | Biology direct ; 12(2017) Artikel-Nummer 18, 17 Seiten |
Teil von: | Cell adhesion heterogeneity reinforces tumour cell dissemination ; volume:12 |
ISSN: |
1745-6150 |
DOI: | 10.1186/s13062-017-0188-z |
Zusammenfassung: | Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate from the primary tumour mass. This complex process depends on intracellular cues that are subject to genetic and epigenetic variability, as well as extrinsic cues from the local environment resulting in a spatial heterogeneity in the adhesive phenotype of individual tumour cells. Here, we use a novel mathematical model to study how adhesion heterogeneity, influenced by intrinsic and extrinsic factors, affects the dissemination of tumour cells from an epithelial cell population. The model is a multiscale cellular automaton that couples intracellular adhesion receptor regulation with cell-cell adhesion. |
Format: | E-Book-Kapitel |
Quelle: |
Verbunddaten SWB Lizenzfreie Online-Ressourcen |
Anmerkungen: | Gesehen am 26.04.2018 |
Sprache: | Englisch |