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An integrative workflow to study large-scale biochemical networks
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Erscheint auch als: | Khan, Faiz Muhammad, 1985 - , An integrative workflow to study large-scale biochemical networks, Rostock, 2019, IX, 194 Seiten |
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Personen und Körperschaften: | , , , , , |
Titel: | An integrative workflow to study large-scale biochemical networks/ vorgelegt von Faiz Khan |
Hochschulschriftenvermerk: | Dissertation, Universität Rostock, 2019 |
veröffentlicht: |
Rostock:
Universität,
2019
Rostock: Universitätsbibliothek |
Umfang: | 1 Online-Ressource |
DOI: | 10.18453/rosdok_id00002554 |
Zusammenfassung: | I propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of large-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research.<eng> |
Format: | E-Book Hochschulschrift |
Quelle: |
Verbunddaten SWB Lizenzfreie Online-Ressourcen |
Anmerkungen: | GutachterInnen: Olaf Wolkenhauer (University of Rostock) ; Jan Hasenauer (University of Bonn) ; Georg Füllen (University of Rostock) |
Sprache: | Englisch |