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Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides
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Personen und Körperschaften: | , , , , , , |
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Titel: |
Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides |
In: | Archiv der Pharmazie, 341, 2008, 5, S. 273-280 |
veröffentlicht: |
Wiley
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Umfang: | 273-280 |
ISSN: |
0365-6233 1521-4184 |
DOI: | 10.1002/ardp.200700190 |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their <jats:italic>in‐vitro</jats:italic> cytotoxicity against various human cancer cell lines and their protein‐kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the tested cell lines. Compound<jats:bold> 6b </jats:bold>is the most promising compound against the tested cancer cell lines;<jats:bold> 6d </jats:bold>and <jats:bold>6e</jats:bold> showed moderate protein‐kinase C inhibition. Structure–activity relationships are discussed based on the experimental data obtained.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |