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Lymphokines and bacteria, that induce tumoricidal activity, trigger a different secretory response in macrophages
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Personen und Körperschaften: | , , |
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Titel: |
Lymphokines and bacteria, that induce tumoricidal activity, trigger a different secretory response in macrophages |
In: | European Journal of Immunology, 20, 1990, 3, S. 695-698 |
veröffentlicht: |
Wiley
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Umfang: | 695-698 |
ISSN: |
0014-2980 1521-4141 |
DOI: | 10.1002/eji.1830200334 |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>The abilities of various macrophage‐activating agents to trigger tumoricidal activity and/or the secretion of prostaglandin E<jats:sub>2</jats:sub> (PGE<jats:sub>2</jats:sub>), interleukin 6 (IL 6) and transforming growth factor β (TGFβ) in bone marrow‐derived mononuclear phagocytes (BMMΦ) <jats:italic>in vitro</jats:italic> were comparatively assessed. Induction of tumoricidal activity by lymphokines, that is only short‐lived, was not associated with enhanced secretion of these activities by BMMΦ; in contrast, incubation with heat‐killed facultative intracellular bacteria resulted in persisting tumoricidal activity and in marked enhancement of the secretion of IL 6 and PGE<jats:sub>2</jats:sub>, but not of TGFβ activity. These findings support the concept that the pattern of the secretory response induced in macrophages by lymphokines differs from that triggered by bacteria and that the rapid decay of lymphokine‐induced tumoricidal activity is not due to autocrine macrophage deactivation mediated by one of these agents alone.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |