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Cytotoxic Amides and Quinolones from Clausena lansium
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Personen und Körperschaften: | , , , , |
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Titel: |
Cytotoxic Amides and Quinolones from Clausena lansium |
In: | Helvetica Chimica Acta, 97, 2014, 2, S. 298-305 |
veröffentlicht: |
Wiley
|
Umfang: | 298-305 |
ISSN: |
0018-019X 1522-2675 |
DOI: | 10.1002/hlca.201300323 |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>Two new amides, claulansamides A and B (<jats:bold>1</jats:bold> and <jats:bold>2</jats:bold>, resp.), together with five known amides, <jats:bold>3</jats:bold>–<jats:bold>7</jats:bold> and six known quinolones, <jats:bold>8</jats:bold>–<jats:bold>13</jats:bold>, were isolated from the stems and roots of <jats:italic>Clausena lansium.</jats:italic> Their structures were elucidated on the basis of extensive spectroscopic methods. Their absolute configurations were determined by single‐crystal X‐ray diffraction technique, CD, and optical rotation. HPLC Chiral separation of <jats:bold>1</jats:bold> afforded two enantiomers, (+)‐ and (−)‐claulansamide A, respectively. Compounds <jats:bold>9, 12</jats:bold>, and <jats:bold>13</jats:bold> were isolated from the genus <jats:italic>Clausena</jats:italic> for the first time. All compounds were evaluated for their cytotoxic activities against A549, BGC‐823, and HeLa cancer cell lines. However, only <jats:bold>9</jats:bold> showed cytotoxic activity against A549 cell line with an <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> value of 46.3 μ<jats:sc>M</jats:sc>, and <jats:bold>11</jats:bold> against BGC‐823 and HeLa cell lines with the <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> values of 55.0 and 14.7 μ<jats:sc>M</jats:sc>, respectively.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |