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Association between glycated albumin, fructosamine, and HbA1c with neonatal outcomes in a prospective cohort of women with gestational diabetes mellitus
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Titel: |
Association between glycated albumin, fructosamine, and HbA1c with neonatal outcomes in a prospective cohort of women with gestational diabetes mellitus |
In: | International Journal of Gynecology & Obstetrics, 146, 2019, 3, S. 326-332 |
veröffentlicht: |
Wiley
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Umfang: | 326-332 |
ISSN: |
0020-7292 1879-3479 |
DOI: | 10.1002/ijgo.12897 |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To investigate whether glycated albumin, fructosamine, and hemoglobin A1c (HbA1c) are associated with neonatal complications in newborns of pregnant women with gestational diabetes mellitus (<jats:styled-content style="fixed-case">GDM</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Between November 2016 and September 2017, women with a singleton pregnancy and <jats:styled-content style="fixed-case">GDM</jats:styled-content> were enrolled in a prospective study in an obstetric Portuguese referral center. Glycemic markers were compared between mothers of newborns with and without complications. Multivariable logistic regression models and corresponding areas under the receiver operating characteristic curve (<jats:styled-content style="fixed-case">AUC</jats:styled-content>) were used.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 85 women participated in the study. Raised levels of glycated albumin and fructosamine were associated with at least one neonatal complication (<jats:styled-content style="fixed-case">OR</jats:styled-content>‐ [odds ratio] estimate: 1.33, <jats:italic>P</jats:italic>=0.015; <jats:styled-content style="fixed-case">OR</jats:styled-content>: 1.24, <jats:italic>P</jats:italic>=0.027, respectively) and with respiratory disorders at birth (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.41, <jats:italic>P</jats:italic>=0.004; <jats:styled-content style="fixed-case">OR</jats:styled-content> 1.26, <jats:italic>P</jats:italic>=0.014, respectively). HbA1c was not associated with these outcomes. All biomarkers were associated with large‐for‐gestational age (<jats:styled-content style="fixed-case">LGA</jats:styled-content>) status (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.61, <jats:italic>P</jats:italic><0.001; <jats:styled-content style="fixed-case">OR</jats:styled-content> 1.45, <jats:italic>P</jats:italic><0.001; <jats:styled-content style="fixed-case">OR</jats:styled-content> 3.62, <jats:italic>P</jats:italic>=0.032 for glycated albumin, fructosamine, and HbA1c, respectively). All had similar <jats:styled-content style="fixed-case">AUC</jats:styled-content> for at least one neonatal complication (0.82; 0.81; 0.79, respectively). For newborn respiratory disorders, <jats:styled-content style="fixed-case">AUC</jats:styled-content>s were 0.83, 0.81, and 0.76, respectively, and for <jats:styled-content style="fixed-case">LGA</jats:styled-content> status were 0.81, 0.79, and 0.71, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Raised values of glycated albumin and fructosamine were associated with particular perinatal complications in newborns of mothers with <jats:styled-content style="fixed-case">GDM</jats:styled-content>, better discriminating mothers of newborns with and without complications than HbA1c.</jats:p></jats:sec> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |