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KCNQ1OT1 hypomethylation: A Novel disguised genetic predisposition in sporadic pediatric adrenocortical tumors?
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Personen und Körperschaften: | , , , , |
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Titel: |
KCNQ1OT1 hypomethylation: A Novel disguised genetic predisposition in sporadic pediatric adrenocortical tumors? |
In: | Pediatric Blood & Cancer, 59, 2012, 3, S. 565-566 |
veröffentlicht: |
Wiley
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Umfang: | 565-566 |
ISSN: |
1545-5009 1545-5017 |
DOI: | 10.1002/pbc.23398 |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>Pediatric adrenal tumors, other than neuroblastoma, are rare and can be associated with a genetic predisposition. In this report we describe two patients with an isolated and apparently sporadic adrenocortical tumor; one girl with a carcinoma, the other girl with an adenoma. In both patients genetic screening revealed hypomethylation of the <jats:italic>KCNQ1OT1</jats:italic> gene, well‐known for its association with the Beckwith–Wiedemann syndrome. This represents a likely <jats:italic>novel</jats:italic> genetic predisposition in patients with adrenocortical tumors without clear phenotypic features of the Beckwith–Wiedemann syndrome. Pediatr Blood Cancer 2012;59:565–566. © 2011 Wiley Periodicals, Inc.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |