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Novel quinoline-derived mTOR inhibitors with remarkable enzymatic and cellular activities: design, synthesis and biological evaluation
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Personen und Körperschaften: | , , , , |
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Titel: |
Novel quinoline-derived mTOR inhibitors with remarkable enzymatic and cellular activities: design, synthesis and biological evaluation |
In: | MedChemComm, 7, 2016, 2, S. 297-310 |
veröffentlicht: |
Royal Society of Chemistry (RSC)
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Umfang: | 297-310 |
ISSN: |
2040-2503 2040-2511 |
DOI: | 10.1039/c5md00401b |
Zusammenfassung: | <p>Compound <bold>24</bold>, obtained <italic>via</italic> a ring-opening strategy, exhibited both attractive mTOR potency and superior cellular activity to initial lead <bold>9</bold>.</p> |
Format: | E-Article |
Quelle: | Royal Society of Chemistry (RSC) (CrossRef) |
Sprache: | Englisch |