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AT1-receptor blockade enhances ischemic preconditioning in hypertrophied rat myocardium
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Personen und Körperschaften: | , , |
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Titel: |
AT1-receptor blockade enhances ischemic preconditioning in hypertrophied rat myocardium |
In: | American Journal of Physiology-Heart and Circulatory Physiology, 277, 1999, 6, S. H2482-H2487 |
veröffentlicht: |
American Physiological Society
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Umfang: | H2482-H2487 |
ISSN: |
0363-6135 1522-1539 |
DOI: | 10.1152/ajpheart.1999.277.6.h2482 |
Zusammenfassung: | <jats:p> The purpose of this study was to determine whether ischemic preconditioning protects contractile function in hypertrophied rat myocardium from ischemia-reperfusion (I/R) injury. Male salt-sensitive rats were fed a high-salt diet for 2 wk to induce myocardial hypertrophy. Nonhypertrophied hearts were obtained from age-matched Sprague-Dawley (SD) rats fed a regular diet. Heart weight-to-body weight ratios were higher in salt-sensitive rats than in SD rats (6.9 ± 0.2 vs. 4.7 ± 0.2 g/kg, P < 0.01). A second group of salt-sensitive and SD rats was administered losartan (10 mg ⋅ kg<jats:sup>−1</jats:sup> ⋅ day<jats:sup>−1</jats:sup>), an AT<jats:sub>1</jats:sub>-receptor blocker, for 1 wk before the study. Isolated hearts were preconditioned with transient ischemia before global I/R. After I/R, preconditioned hypertrophied hearts exhibited greater recovery of left ventricular developed pressure compared with that of preconditioned normal hearts (73 ± 8 vs. 18 ± 8%, P < 0.01). Left ventricular developed pressure was further enhanced by losartan in both hypertrophied and normal myocardium (99 ± 5 vs. 73 ± 8%, P < 0.05 and 97 ± 15 vs. 18 ± 8%, P < 0.01). Hypertrophied rat myocardium can be protected from I/R-induced contractile dysfunction by ischemic preconditioning. Losartan improves the ischemic tolerance of normal and hypertrophied myocardium. </jats:p> |
Format: | E-Article |
Quelle: | American Physiological Society (CrossRef) |
Sprache: | Englisch |