Eintrag weiter verarbeiten
Dendritic-NK Cell Interactions inP. gingivalis-specific Responses
Gespeichert in:
Personen und Körperschaften: | , , , , , , , |
---|---|
Titel: |
Dendritic-NK Cell Interactions inP. gingivalis-specific Responses |
In: | Journal of Dental Research, 84, 2005, 9, S. 858-862 |
veröffentlicht: |
SAGE Publications
|
Umfang: | 858-862 |
ISSN: |
0022-0345 1544-0591 |
DOI: | 10.1177/154405910508400915 |
Zusammenfassung: | <jats:p>Patients with localized aggressive periodontitis have type-1 cytokines in gingival crevicular fluid and high titers of IFN-γ-dependent IgG2 reactive with P. gingivalis in gingival crevicular fluid and serum. Localized aggressive periodontitis monocytes spontaneously differentiate into dendritic cells that can stimulate IFN-γ production by NK cells. These relationships prompted the hypothesis that P. gingivalis-dendritic cell-NK cell interactions might promote type-1 cytokine responses. Although P. gingivalis is not a potent inducer of Th1 responses, it stimulated strong IL-12 responses by monocyte-derived dendritic cells in the presence of IFN-γ, and IFN-γ was produced by NK cells within 24 hrs in the presence of dendritic cells. Anti- P. gingivalis IgG2 responses were enhanced by dendritic cells, and removal of NK cells reduced IFN-γ- and P. gingivalis-specific IgG2. Thus, P. gingivalis-dendritic cell-NK cell interactions apparently resulted in reciprocal stimulation and increased type-1 cytokine production by both dendritic cells and NK cells, and increased P. gingivalis-specific IgG2.</jats:p> |
Format: | E-Article |
Quelle: | SAGE Publications (CrossRef) |
Sprache: | Englisch |