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A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells
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Titel: |
A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells |
In: | Blood, 109, 2007, 7, S. 2985-2988 |
veröffentlicht: |
American Society of Hematology
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Umfang: | 2985-2988 |
ISSN: |
0006-4971 1528-0020 |
DOI: | 10.1182/blood-2006-07-032839 |
Zusammenfassung: | <jats:title>Abstract</jats:title> <jats:p>The FLT3 receptor tyrosine kinase is expressed in more than 90% of acute myelogeneous leukemias (AMLs), up to 30% of which carry an internal tandem duplication (ITD) within the FLT3 gene. Although varying duplication sites exist, most FLT3-ITDs affect a single protein domain. We analyzed the FLT3-ITD of an AML patient for encoding HLA class I–restricted immunogenic peptides. One of the tested peptides (YVDFREYEYY) induced in vitro autologous T-cell responses restricted by HLA-A*0101 that were also detectable ex vivo. These peptide-reactive T cells recognized targets transfected with the patient's FLT3-ITD, but not wild-type FLT3, and recognized the patient's AML cells. Our results demonstrate that AML leukemic blasts can in principle process and present immunogenic FLT3-ITD neoepitopes. Therefore, FLT3-ITD represents a potential candidate target antigen for the immunotherapy of AML.</jats:p> |
Format: | E-Article |
Quelle: | American Society of Hematology (CrossRef) |
Sprache: | Englisch |