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Telomere length is a critical determinant for survival in multiple myeloma
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Personen und Körperschaften: | , , , , , , , , , , |
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Titel: |
Telomere length is a critical determinant for survival in multiple myeloma |
In: | British Journal of Haematology, 178, 2017, 1, S. 94-98 |
veröffentlicht: |
Wiley
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Umfang: | 94-98 |
ISSN: |
0007-1048 1365-2141 |
DOI: | 10.1111/bjh.14643 |
Zusammenfassung: | <jats:title>Summary</jats:title><jats:p>The variable clinical outcomes of Multiple Myeloma (<jats:styled-content style="fixed-case">MM</jats:styled-content>) patients are incompletely defined by current prognostication tools. We examined the clinical utility of high‐resolution telomere length analysis as a prognostic marker in <jats:styled-content style="fixed-case">MM</jats:styled-content>. Cohort stratification, using a previously determined length threshold for telomere dysfunction, revealed that patients with short telomeres had a significantly shorter overall survival (<jats:italic>P </jats:italic><<jats:italic> </jats:italic>0·0001; <jats:styled-content style="fixed-case">HR</jats:styled-content> = 3·4). Multivariate modelling using forward selection identified International Staging System (<jats:styled-content style="fixed-case">ISS</jats:styled-content>) stage as the most important prognostic factor, followed by age and telomere length. Importantly, each <jats:styled-content style="fixed-case">ISS</jats:styled-content> prognostic subset could be further risk‐stratified according to telomere length, supporting the inclusion of this parameter as a refinement of the <jats:styled-content style="fixed-case">ISS</jats:styled-content>.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |