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Changes in arginine are inversely associated with type 2 diabetes: A case‐cohort study in the PREDIMED trial
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Titel: |
Changes in arginine are inversely associated with type 2 diabetes: A case‐cohort study in the PREDIMED trial |
In: | Diabetes, Obesity and Metabolism, 21, 2019, 2, S. 397-401 |
veröffentlicht: |
Wiley
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Umfang: | 397-401 |
ISSN: |
1462-8902 1463-1326 |
DOI: | 10.1111/dom.13514 |
Zusammenfassung: | <jats:p>The associations between arginine‐based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case‐cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N‐monomethyl‐l‐arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1‐year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; <jats:italic>P</jats:italic> trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; <jats:italic>P</jats:italic> trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1‐year changes in homeostatic model assessment of insulin resistance. Individuals in the low‐fat‐diet group had a higher risk of T2D for 1‐year changes in NMMA than individuals in Mediterranean‐diet groups (<jats:italic>P</jats:italic> interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |