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Diagnostics of virus‐induced anterior uveitis
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Titel: |
Diagnostics of virus‐induced anterior uveitis |
In: | Acta Ophthalmologica, 89, 2011, s248, S. 0-0 |
veröffentlicht: |
Wiley
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Umfang: | 0-0 |
ISSN: |
1755-375X 1755-3768 |
DOI: | 10.1111/j.1755-3768.2011.4445.x |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p><jats:bold>Purpose</jats:bold> Virally induced anterior uveitis, accounting for more than 10 % of cases, is the most common form of infectious anterior uveitis. A distinction between the various possible infectious agents is important for therapy and prognosis, but frequently not possible basing only on history and clinical grounds only. In these cases, a laboratory confirmation of the clinically presumed diagnosis is of interest.</jats:p><jats:p><jats:bold>Methods</jats:bold> A Medline search was conducted using the search terms “anterior uveitis”, “virus” and “diagnostic”. After exclusion of reviews and studies including less than ten samples, the remaining were assessed for their diagnostic yield with focus on the viruses of the herpes family (HSV‐1, HSV‐2, VZV, CMV, EBV, HHV6‐8), Rubella and Parechovirus including ELISA, PCR and immunoblot testing from paired samples of aqueous humour and serum.</jats:p><jats:p><jats:bold>Results</jats:bold> Based on intraocular antibody synthesis and PCR, herpes vriuses represent the majority of viral anterior uveitis instances. Cytomagalovirus‐ and Rubella‐associated anterior uveitis have obviously been underestimated in their role, whereas the clinical relevance of Parechovirus and other forms of more recently described viral anterior uveitis cases has as yet to be determined.</jats:p><jats:p><jats:bold>Conclusion</jats:bold> Basing on published evidence, a systematic diagnosis of infectious agents in presumed viral anterior uveitis has to be postulated for all cases without a clear clinical diagnosis or a poor response to therapy. If access to a qualified laboratory is lacking, a parallel sample of serum and aqueous humour should be collected and be referred to one of the international referrence laboratories if the clinical situation is developing unfavourably.</jats:p> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |