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Short‐ and Long‐Term Cure Rates of Short‐Duration Trimethoprim‐Sulfamethoxazole Treatment in Female Dogs with Uncomplicated Bacterial Cystitis
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Titel: |
Short‐ and Long‐Term Cure Rates of Short‐Duration Trimethoprim‐Sulfamethoxazole Treatment in Female Dogs with Uncomplicated Bacterial Cystitis |
In: | Journal of Veterinary Internal Medicine, 28, 2014, 3, S. 818-826 |
veröffentlicht: |
Wiley
|
Umfang: | 818-826 |
ISSN: |
0891-6640 1939-1676 |
DOI: | 10.1111/jvim.12324 |
Zusammenfassung: | <jats:sec><jats:title>Background</jats:title><jats:p>Long‐duration beta‐lactam antibiotics are used for empirical treatment in female dogs with uncomplicated bacterial cystitis. However, women with bacterial cystitis are treated with short‐duration potentiated sulfonamides because longer courses of beta‐lactams result in lower cure and higher recurrence rates.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>Short‐duration potentiated sulfonamide treatment is more efficacious than long‐duration beta‐lactam treatment in achieving clinical and microbiological cures in female dogs with uncomplicated bacterial cystitis.</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>Thirty‐eight client‐owned female dogs.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Randomized, double‐blinded, placebo‐controlled clinical trial. Dogs were treated with <jats:styled-content style="fixed-case">TMP</jats:styled-content>‐<jats:styled-content style="fixed-case">SMX</jats:styled-content> (15 mg/kg <jats:styled-content style="fixed-case">PO</jats:styled-content> q12h for 3 days followed by a placebo capsule <jats:styled-content style="fixed-case">PO</jats:styled-content> q12h for 7 days; Group <jats:styled-content style="fixed-case">SDS</jats:styled-content>; n = 20) or cephalexin (20 mg/kg <jats:styled-content style="fixed-case">PO</jats:styled-content> q12h for 10 days; Group <jats:styled-content style="fixed-case">LDBL</jats:styled-content>; n = 18). Dogs were monitored for clinical and microbiological cure during treatment and at short‐ and long‐term follow‐up.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No statistically significant differences were found between treatment groups in clinical cure rates after 3 days of treatment (89% <jats:styled-content style="fixed-case">SDS</jats:styled-content>, 94% <jats:styled-content style="fixed-case">LDBL</jats:styled-content>;<jats:italic> P</jats:italic> = 1.00) and 4 days (85% <jats:styled-content style="fixed-case">SDS</jats:styled-content>, 72% <jats:styled-content style="fixed-case">LDBL</jats:styled-content>;<jats:italic> P</jats:italic> = .44) or >30 days (50% <jats:styled-content style="fixed-case">SDS</jats:styled-content>, 65% <jats:styled-content style="fixed-case">LDBL</jats:styled-content>;<jats:italic> P</jats:italic> = .50) after conclusion of treatment or in microbiological cure rates 4 days (59% <jats:styled-content style="fixed-case">SDS</jats:styled-content>, 36% <jats:styled-content style="fixed-case">LDBL</jats:styled-content>;<jats:italic> P</jats:italic> = .44) or >30 days (44% <jats:styled-content style="fixed-case">SDS</jats:styled-content>, 20% <jats:styled-content style="fixed-case">LDBL</jats:styled-content>;<jats:italic> P</jats:italic> = .40) after conclusion of treatment.</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance</jats:title><jats:p>We did not identify a difference in cure rates between short‐duration sulfonamide and long‐duration beta‐lactam treatments in female dogs with uncomplicated cystitis. Long‐term cure rates in both treatment groups were low. In some female dogs, “uncomplicated” bacterial cystitis may be more complicated than previously recognized.</jats:p></jats:sec> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |