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Prevalence of depression symptoms and serum levels of interleukin‐6 in hemodialysis patients
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Personen und Körperschaften: | , , , , , , , , , , |
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Titel: |
Prevalence of depression symptoms and serum levels of interleukin‐6 in hemodialysis patients |
In: | Psychiatry and Clinical Neurosciences, 68, 2014, 4, S. 275-282 |
veröffentlicht: |
Wiley
|
Umfang: | 275-282 |
ISSN: |
1323-1316 1440-1819 |
DOI: | 10.1111/pcn.12130 |
Zusammenfassung: | <jats:sec><jats:title>Aim</jats:title><jats:p>In hemodialysis patients, depression appears as the most common psychopathological condition. States of advanced chronic kidney disease and dialysis are associated with a state of chronic inflammation. Depression has been linked to activation of the immune system characterized by high levels of pro‐inflammatory cytokines. In this study, we investigated the possible correlations between depression, and interleukin‐6 (<jats:styled-content style="fixed-case">IL</jats:styled-content>‐6) in hemodialysis patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Seventy‐five hemodialysis patients were enrolled in a cross‐sectional study from <jats:styled-content style="fixed-case">S</jats:styled-content>eptember to <jats:styled-content style="fixed-case">N</jats:styled-content>ovember 2011 in <jats:styled-content style="fixed-case">P</jats:styled-content>elotas, Rio Grande do Sul. Demographic data were obtained from a questionnaire and the Beck Depression Inventory (<jats:styled-content style="fixed-case">BDI</jats:styled-content>) was used to determine the presence or absence of depression symptoms. Biochemical parameters, dialysisdosage delivery, and <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 serum levels were measured.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Prevalence of depression among hemodialysis patients was 48% (<jats:styled-content style="fixed-case">BDI</jats:styled-content> ≥ 14). In biochemical assessments, depressed patients showed a decrease in urea (<jats:italic>P</jats:italic> = 0.01) and increase of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 (<jats:italic>P</jats:italic> = 0.04) levels. The correlation analysis between <jats:styled-content style="fixed-case">BDI</jats:styled-content> scores and the biochemical variables showed that <jats:styled-content style="fixed-case">BDI</jats:styled-content> was negatively correlated with urea (<jats:italic>P</jats:italic> = 0.03) and potassium (<jats:italic>P</jats:italic> = 0.04), but not with <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 levels.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Hemodialysis patients with depression showed higher levels of <jats:styled-content style="fixed-case">IL</jats:styled-content>‐6 but the severity of depressive symptoms was not correlated with levels of this cytokine.</jats:p></jats:sec> |
Format: | E-Article |
Quelle: | Wiley (CrossRef) |
Sprache: | Englisch |