Eintrag weiter verarbeiten
Cure of Xenografted Human Tumors by Bispecific Monoclonal Antibodies and Human T Cells
Gespeichert in:
Personen und Körperschaften: | , , , , , , , , , |
---|---|
Titel: |
Cure of Xenografted Human Tumors by Bispecific Monoclonal Antibodies and Human T Cells |
In: | Science, 264, 1994, 5160, S. 833-835 |
veröffentlicht: |
American Association for the Advancement of Science (AAAS)
|
Umfang: | 833-835 |
ISSN: |
0036-8075 1095-9203 |
DOI: | 10.1126/science.8171337 |
Zusammenfassung: | <jats:p>Tumor immunotherapy should increase both the number of T cells that kill the tumor and the likelihood that those cells are activated at the tumor site. Bispecific monoclonal antibodies (Bi-mAbs) were designed that bound to a Hodgkin's tumor-associated antigen (CD30) on the tumor and to either CD3 or CD28 on the T cell. Immunodeficient mice were cured of established human tumors when mice were treated with both the CD3-CD30 and the CD28-CD30 Bi-mAbs and then given human peripheral blood lymphocytes that had been incubated with the CD3-CD30 Bi-mAb and cells that expressed CD30. The enrichment of human T cells within the tumor and the fact that established tumors can be cured may indicate in situ activation of both the T cell receptor and the costimulatory pathway.</jats:p> |
Format: | E-Article |
Quelle: | American Association for the Advancement of Science (AAAS) (CrossRef) |
Sprache: | Englisch |