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Host-response biomarkers for the diagnosis of bacterial respiratory tract infections
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Personen und Körperschaften: | , , |
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Titel: |
Host-response biomarkers for the diagnosis of bacterial respiratory tract infections |
In: | Clinical Chemistry and Laboratory Medicine (CCLM), 57, 2019, 4, S. 442-451 |
veröffentlicht: |
Walter de Gruyter GmbH
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Umfang: | 442-451 |
ISSN: |
1437-4331 1434-6621 |
DOI: | 10.1515/cclm-2018-0682 |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>Appropriate antibiotic treatment for respiratory tract infections (RTIs) necessitates rapid and accurate diagnosis of microbial etiology, which remains challenging despite recent innovations. Several host response-based biomarkers due to infection have been suggested to allow discrimination of bacterial and non-bacterial microbial RTI etiology. This review provides an overview of clinical studies that investigated the diagnostic performance of host-response proteomic biomarkers to identify RTI microbial etiology. Procalcitonin and C-reactive protein have been studied most extensively; whereof procalcitonin has demonstrated the strongest diagnostic performance compared to other biomarkers. Proadrenomedullin, soluble triggering receptor expressed on myeloid cells-1, neopterin and pentraxin-3 need more studies to confirm their diagnostic value. For syndecan-4 and lipocalin-2 currently insufficient evidence exists. Common limitations in several of the studies were the relatively small scale setting, heterogeneous patient population and the absence of statistical power calculation.</jats:p> |
Format: | E-Article |
Quelle: | Walter de Gruyter GmbH (CrossRef) |
Sprache: | Englisch |