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Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters
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Titel: |
Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters |
In: | International Journal of Molecular Sciences, 20, 2019, 9, S. 2347 |
veröffentlicht: |
MDPI AG
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Umfang: | 2347 |
ISSN: |
1422-0067 |
DOI: | 10.3390/ijms20092347 |
Zusammenfassung: | <jats:p>The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as β-catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis.</jats:p> |
Format: | E-Article |
Quelle: | MDPI AG (CrossRef) |
Sprache: | Englisch |