Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells

Bibliographic Details
Authors and Corporations: Quincozes-Santos, André
Title: Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells
In: Molecular and Cellular Biochemistry, 314, 2008, 1, p. 59-63
published:
Springer US
Physical Description:59-63
ISSN/ISBN: 0300-8177
1573-4919
EISSN:1573-4919
Summary:We investigated the effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 glioma cells, considering the putative involvement of astroglial cells in neuropsychiatric disorders. In the presence of high experimental doses of risperidone, C6 cells become stellate, with process-bearing cells and partial retraction of the cell body followed by detachment from the adhesion surface with practically no cell death. These results indicate that risperidone is able to interfere with C6 cell adhesion without toxic effects. RhoA activator LPA prevented the effects of risperidone on cell morphology. From 6 h risperidone induced a statistically significant increment of about 80% in S100B secretion. These data contribute to the proposal that glial cells are targets of risperidone, which could be involved in the therapeutic response of risperidone to improve autism symptoms.
Type of Resource:E-Article
Source:Springer Journals
sid-105-col-springerjournals
Language: English