Fast manipulation of cellular cAMP level by light in vivo

Bibliographic Details
Authors and Corporations: Schröder-Lang, Saskia, Schwärzel, Martin, Seifert, Reinhard, Strünker, Timo, Kateriya, Suneel, Looser, Jens, Watanabe, Masakatsu, Kaupp, U Benjamin, Hegemann, Peter, Nagel, Georg
Title: Fast manipulation of cellular cAMP level by light in vivo
published:
Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2006
Summary:The flagellate Euglena gracilis contains a photoactivated adenylyl cyclase (PAC), consisting of the flavoproteins PACa and PACb. Here we report functional expression of PACs in Xenopus laevis oocytes, HEK293 cells and in Drosophila melanogaster, where neuronal expression yields light-induced changes in behavior. The activity of PACs is strongly and reversibly enhanced by blue light, providing a powerful tool for light-induced manipulation of cAMP in animal cells. ; Peer Reviewed
Type of Resource:E-Article
Source:Open-Access-Publikationsserver der Humboldt-Universität: edoc-Server
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Language: English